Cefexime is a drug of choice in the treatment of susceptible infections including gonorrhoea, otitis media, pharyngitis, bronchitis and urinary tract infections. The present work was carried out to improve the solubility, dissolution rate, oral bioavailability, stability and palatability of the drug Cefixime by forming it as a reconstitutable oral suspension especially for pediatric use. The poorly soluble drug, Cefixime is formulated as reconstitutable suspension using xanthan gum, olibanum gum, karaya gum, HPMC E5, compound tragacanth powder (CTP) as suspending agents employing various techniques like physical mixing, solvent evaporation and co-grinding. The reconstitutable suspensions were evaluated for flow properties, particle size, pH, viscosity, sedimentation volume, redispersibility and drug release by in vitro dissolution studies. The drug excipients interaction and crystal morphology of optimized reconstitutable suspensions were evaluated by Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) studies, respectively. The results indicated that the release of the cefixime was rapid from all formulations than the pure drug. The drug release from the suspensions followed first order kinetics. Among all formulations the formulation prepared by kneading method released the drug rapidly than the pure drug and other formulations.
Loading....